Research Summary
Donald Hedeker's chief expertise is in the development and use of advanced statistical methods for clustered and longitudinal data, with particular emphasis on mixed-effects models. He is the primary author of several freeware computer programs for mixed-effects analysis. With Robert Gibbons, Don is the author of the text “Longitudinal Data Analysis,” published by Wiley in 2006. More recently, he has developed methods and software for analysis of intensive longitudinal data, which are data with many measurements over time, often collected using mobile devices and/or the internet. Such data are increasingly obtained by researchers in many research areas, for example in the areas of mobile health (mHealth) and ecological momentary assessment (EMA) studies. He is an associate editor for Statistics in Medicine.
longitudinal data analysis, ecological momentary assessment, ordinal data, mixed-effects models
  • University of Chicago, Chicago, BA Economics 06/1980
  • University of Chicago, Chicago, PhD Quantitative Psychology 03/1989
Biosciences Graduate Program Association
Awards & Honors
  • 2000 - Fellow, American Statistical Association American Statistical Association
  • 2015 - Elected Member, International Statistical Institute International Statistical Institute
  • 2015 - Long-Term Excellence Award, Health Policy Statistics Section ASA Health Policy Statistics Section ASA
  • 2016 - Elected Member, Society of Multivariate Experimental Psychology Society of Multivariate Experimental Psychology
  1. Dzubur E, Semborski S, Redline B, Hedeker D, Dunton GF, Henwood BF. Food insecurity, hunger, stress, and homelessness among young adults. Health Psychol. 2022 Aug; 41(8):559-565. View in: PubMed

  2. Zhang X, Hedeker D. Defining R-squared measures for mixed-effects location scale models. Stat Med. 2022 Jul 07. View in: PubMed

  3. Maher JP, Wang WL, Hedeker D, Dunton GF. Temporal stability of behavior, temporal cue-behavior associations, and physical activity habit strength among mothers with school-aged children. Psychol Health. 2022 Jun 27; 1-16. View in: PubMed

  4. Lahey BB, Tong L, Pierce B, Hedeker D, Berman MG, Cardenas-Iniguez C, Moore TM, Applegate B, Tiemeier H, Kaczkurkin AN. Associations of polygenic risk for attention-deficit/hyperactivity disorder with general and specific dimensions of childhood psychological problems and facets of impulsivity. J Psychiatr Res. 2022 Aug; 152:187-193. View in: PubMed

  5. Cohn AM, Pickworth W, Audrain-McGovern J, Murphy J, Villanti AC, Hedeker D, Dunn D, Wyatt R, Niznik T, Cotten W, Smith M, Ehlke SJ. Measuring young adult appeal for menthol and non-menthol cigarettes: protocol of a clinical trial using both laboratory and intensive longitudinal methods (PRISM). BMJ Open. 2022 04 28; 12(4):e058823. View in: PubMed

  6. Dunton GF, Wang WL, Intille SS, Dzubur E, Ponnada A, Hedeker D. How acute affect dynamics impact longitudinal changes in physical activity among children. J Behav Med. 2022 06; 45(3):451-460. View in: PubMed

  7. Ma Q, Mermelstein RJ, Hedeker D. A shared-parameter location-scale mixed model to link the responsivity in self-initiated event reports and the event-contingent Ecological Momentary Assessments. Stat Med. 2022 05 10; 41(10):1780-1796. View in: PubMed

  8. Santos C, Bustamante A, Vasconcelos O, Pereira S, Garganta R, Lightfoot JT, Tani G, Hedeker D, Katzmarzyk PT, Maia J. Sibling Resemblances in Physical Fitness in Three Distinct Regions in Peru: The Peruvian Sibling Study on Growth and Health. Behav Genet. 2022 05; 52(3):195-204. View in: PubMed

  9. Kendall AD, Hedeker D, Diviak KR, Mermelstein RJ. The Mood Boost from Tobacco Cigarettes is More Erratic with the Additions of Cannabis and Alcohol. Nicotine Tob Res. 2022 07 13; 24(8):1169-1176. View in: PubMed

  10. Yaremych HE, Preacher KJ, Hedeker D. Centering categorical predictors in multilevel models: Best practices and interpretation. Psychol Methods. 2021 Dec 16. View in: PubMed

  11. Press DJ, Shariff-Marco S, Lichtensztajn DY, Lauderdale D, Murphy AB, Inamdar PP, DeRouen MC, Hamilton AS, Yang J, Lin K, Hedeker D, Haiman CA, Cheng I, Gomez SL. Contributions of Social Factors to Disparities in Prostate Cancer Risk Profiles among Black Men and Non-Hispanic White Men with Prostate Cancer in California. Cancer Epidemiol Biomarkers Prev. 2022 02; 31(2):404-412. View in: PubMed

  12. Lin X, Mermelstein R, Hedeker D. Analysis of multivariate longitudinal substance use outcomes using multivariate mixed cumulative logit model. BMC Med Res Methodol. 2021 11 06; 21(1):239. View in: PubMed

  13. Park M, Choi Y, Yasui M, Hedeker D. Racial discrimination and the moderating effects of racial and ethnic socialization on the mental health of Asian American youth. Child Dev. 2021 11; 92(6):2284-2298. View in: PubMed

  14. Pereira S, Bustamante A, Santos C, Hedeker D, Tani G, Garganta R, Vasconcelos O, Baxter-Jones A, Katzmarzyk PT, Maia J. Biological and environmental influences on motor coordination in Peruvian children and adolescents. Sci Rep. 2021 07 29; 11(1):15444. View in: PubMed

  15. Kim S, Selya A, Wakschlag LS, Dierker L, Rose JS, Hedeker D, Mermelstein RJ. Estimating causal and time-varying effects of maternal smoking on youth smoking. Addict Behav. 2021 09; 120:106982. View in: PubMed

  16. Weber TL, Selya A, Wakschlag LS, Dierker L, Rose JS, Hedeker D, Mermelstein RJ. The Effect of Maternal Smoking on Offspring Smoking Is Unrelated to Heritable Personality Traits or Initial Subjective Experiences. Nicotine Tob Res. 2021 08 29; 23(10):1754-1762. View in: PubMed

  17. Brett EI, Chavarria J, Liu M, Hedeker D, King AC. Effects of a brief motivational smoking intervention in non-treatment seeking disadvantaged Black smokers. J Consult Clin Psychol. 2021 Apr; 89(4):241-250. View in: PubMed

  18. Spring B, Stump TK, Battalio SL, McFadden HG, Fidler Pfammatter A, Alshurafa N, Hedeker D. Digitally characterizing the dynamics of multiple health behavior change. Health Psychol. 2021 Dec; 40(12):897-908. View in: PubMed

  19. Shang L, Hattori M, Fleming G, Jaskowiak N, Hedeker D, Olopade OI, Huo D. Impact of post-diagnosis weight change on survival outcomes in Black and White breast cancer patients. Breast Cancer Res. 2021 02 04; 23(1):18. View in: PubMed

  20. Cardenas-Iniguez C, Moore TM, Kaczkurkin AN, Meyer FAC, Satterthwaite TD, Fair DA, White T, Blok E, Applegate B, Thompson LM, Rosenberg MD, Hedeker D, Berman MG, Lahey BB. Direct and Indirect Associations of Widespread Individual Differences in Brain White Matter Microstructure With Executive Functioning and General and Specific Dimensions of Psychopathology in Children. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 04; 7(4):362-375. View in: PubMed

  21. Ma Q, Dunton GF, Hedeker D. A Mixed Effect Location-Scale Model with Mixture Distributed Scale Random Effects to Analyze (Near) Identical Entries in Ecological Momentary Assessments. Multivariate Behav Res. 2021 Jan-Feb; 56(1):160. View in: PubMed

  22. Mermelstein RJ, Hedeker D, Rest EC. Response To: Can We Measure Nicotine Dependence in Dual Users of Cigarettes and ENDS? Nicotine Tob Res. 2021 05 04; 23(5):874-875. View in: PubMed

  23. Yang CH, Maher JP, Ponnada A, Dzubur E, Nordgren R, Intille S, Hedeker D, Dunton GF. An empirical example of analysis using a two-stage modeling approach: within-subject association of outdoor context and physical activity predicts future daily physical activity levels. Transl Behav Med. 2021 04 26; 11(4):912-920. View in: PubMed

  24. Ma Q, Mermelstein R, Hedeker D. A Three-Level Mixed Model to Account for the Correlation at both the Between-Day and the Within-Day Level for Ecological Momentary Assessments. Health Serv Outcomes Res Methodol. 2020 Dec; 20(4):247-264. View in: PubMed

  25. Kim K, Polite B, Hedeker D, Liebovitz D, Randal F, Jayaprakash M, Quinn M, Lee SM, Lam H. Implementing a multilevel intervention to accelerate colorectal cancer screening and follow-up in federally qualified health centers using a stepped wedge design: a study protocol. Implement Sci. 2020 10 29; 15(1):96. View in: PubMed

  26. Rest EC, Mermelstein RJ, Hedeker D. Nicotine Dependence in Dual Users of Cigarettes and E-Cigarettes: Common and Distinct Elements. Nicotine Tob Res. 2021 03 19; 23(4):662-668. View in: PubMed

  27. Press DJ, Pierce B, Lauderdale DS, Aschebrook-Kilfoy B, Lin Gomez S, Hedeker D, Wright NE, Fantus RJ, Bettencourt L, Ahsan H, Eggener S. Tobacco and marijuana use and their association with serum prostate-specific antigen levels among African American men in Chicago. Prev Med Rep. 2020 Dec; 20:101174. View in: PubMed

  28. Huisingh-Scheetz M, Wroblewski K, Waite L, Huang ES, Schumm LP, Hedeker D. Variability in Hourly Activity Levels: Statistical Noise or Insight Into Older Adult Frailty? J Gerontol A Biol Sci Med Sci. 2021 08 13; 76(9):1608-1618. View in: PubMed

  29. Pfammatter AF, Champion KE, Finch LE, Siddique J, Hedeker D, Spring B. A mHealth intervention to preserve and promote ideal cardiovascular health in college students: Design and protocol of a cluster randomized controlled trial. Contemp Clin Trials. 2020 11; 98:106162. View in: PubMed

  30. Moore TM, Kaczkurkin AN, Durham EL, Jeong HJ, McDowell MG, Dupont RM, Applegate B, Tackett JL, Cardenas-Iniguez C, Kardan O, Akcelik GN, Stier AJ, Rosenberg MD, Hedeker D, Berman MG, Lahey BB. Correction to Moore et al. (2020). J Abnorm Psychol. 2020 Oct; 129(7):759. View in: PubMed

  31. Santos C, Bustamante A, Hedeker D, Vasconcelos O, Garganta R, Katzmarzyk PT, Maia J. A multilevel analysis of gross motor coordination of children and adolescents living at different altitudes: the Peruvian Health and Optimist Growth Study. Ann Hum Biol. 2020 Jun; 47(4):355-364. View in: PubMed

  32. Dos Santos CSP, Bustamante A, Hedeker D, Vasconcelos O, Garganta R, Tani G, Katzmarzyk PT, Maia J. A multivariate multilevel analysis of youth motor competence. The Peruvian Health and Optimist Growth Study. Scand J Med Sci Sports. 2020 Dec; 30(12):2408-2419. View in: PubMed

  33. Moore TM, Kaczkurkin AN, Durham EL, Jeong HJ, McDowell MG, Dupont RM, Applegate B, Tackett JL, Cardenas-Iniguez C, Kardan O, Akcelik GN, Stier AJ, Rosenberg MD, Hedeker D, Berman MG, Lahey BB. Criterion validity and relationships between alternative hierarchical dimensional models of general and specific psychopathology. J Abnorm Psychol. 2020 Oct; 129(7):677-688. View in: PubMed

  34. Spring B, Pfammatter AF, Marchese SH, Stump T, Pellegrini C, McFadden HG, Hedeker D, Siddique J, Jordan N, Collins LM. A Factorial Experiment to Optimize Remotely Delivered Behavioral Treatment for Obesity: Results of the Opt-IN Study. Obesity (Silver Spring). 2020 09; 28(9):1652-1662. View in: PubMed

  35. Press DJ, Aschebrook-Kilfoy B, Lauderdale D, Stepniak E, Gomez SL, Johnson EP, Gopalakrishnan R, Smieliauskas F, Hedeker D, Bettencourt L, Anselin L, Ahsan H. ChicagO Multiethnic Prevention and Surveillance Study (COMPASS): Increased Response Rates Among African American Residents in Low Socioeconomic Status Neighborhoods. J Racial Ethn Health Disparities. 2021 02; 8(1):186-198. View in: PubMed

  36. Shaffer KM, Hedeker D, Morin CM, Ingersoll K, Thorndike F, Ritterband LM. Intraindividual variability in sleep schedule: effects of an internet-based cognitive-behavioral therapy for insomnia program and its relation with symptom remission. Sleep. 2020 12 14; 43(12). View in: PubMed

  37. Santos C, Bustamante A, Vasconcelos O, Pereira S, Garganta R, Tani G, Hedeker D, Katzmarzyk PT, Maia J. Stunting and Physical Fitness. The Peruvian Health and Optimist Growth Study. Int J Environ Res Public Health. 2020 05 15; 17(10). View in: PubMed

  38. Shiffman S, Scholl SM, Mao J, Ferguson SG, Hedeker D, Tindle HA. Ecological momentary assessment of temptations and lapses in non-daily smokers. Psychopharmacology (Berl). 2020 Aug; 237(8):2353-2365. View in: PubMed

  39. Yuan C, Hedeker D, Mermelstein R, Xie H. A tractable method to account for high-dimensional nonignorable missing data in intensive longitudinal data. Stat Med. 2020 09 10; 39(20):2589-2605. View in: PubMed

  40. Shiffman S, Ferguson SG, Mao J, Scholl SM, Hedeker D, Tindle HA. Effectiveness of nicotine gum in preventing lapses in the face of temptation to smoke among non-daily smokers: a secondary analysis. Addiction. 2020 11; 115(11):2123-2129. View in: PubMed

  41. Asvat Y, King AC, Smith LJ, Lin X, Hedeker D, Henderson TO. Substance use behaviors in adolescent and young adult cancer patients: Associations with mental and physical health. Psychooncology. 2020 06; 29(6):1068-1076. View in: PubMed

  42. Pereira S, Katzmarzyk PT, Hedeker D, Maia J. Change and Stability in Sibling Physical Fitness: The Portuguese Sibling Study. Med Sci Sports Exerc. 2020 07; 52(7):1511-1517. View in: PubMed

  43. Wilhelm J, Abudayyeh H, Perreras L, Taylor R, Peters EN, Vandrey R, Hedeker D, Mermelstein R, Cohn A. Measuring the temporal association between cannabis and tobacco use among Co-using young adults using ecological momentary assessment. Addict Behav. 2020 05; 104:106250. View in: PubMed

  44. Dzubur E, Ponnada A, Nordgren R, Yang CH, Intille S, Dunton G, Hedeker D. MixWILD: A program for examining the effects of variance and slope of time-varying variables in intensive longitudinal data. Behav Res Methods. 2020 08; 52(4):1403-1427. View in: PubMed

  45. Nordgren R, Hedeker D, Dunton G, Yang CH. Extending the mixed-effects model to consider within-subject variance for Ecological Momentary Assessment data. Stat Med. 2020 02 28; 39(5):577-590. View in: PubMed

  46. Pereira S, Katzmarzyk PT, Hedeker D, Maia J. Change and Stability in Sibling Resemblance in Obesity Markers: The Portuguese Sibling Study on Growth, Fitness, Lifestyle, and Health. J Obes. 2019; 2019:2432131. View in: PubMed

  47. Spring B, Klyachko EA, Rak PW, McFadden HG, Hedeker D, Siddique J, Bardsley LR, Pfammatter AF. Online, cross-disciplinary team science training for health and medical professionals: Evaluation of COALESCE ( J Clin Transl Sci. 2019 Jun; 3(2-3):82-89. View in: PubMed

  48. Rubin DS, Huisingh-Scheetz M, Hung A, Ward RP, Nagele P, Arena R, Hedeker D. Accuracy of Physical Function Questions to Predict Moderate-Vigorous Physical Activity as Measured by Hip Accelerometry. Anesthesiology. 2019 11; 131(5):992-1003. View in: PubMed

  49. Santos C, Bustamante A, Hedeker D, Vasconcelos O, Garganta R, Katzmarzyk PT, Maia J. Correlates of Overweight in Children and Adolescents Living at Different Altitudes: The Peruvian Health and Optimist Growth Study. J Obes. 2019; 2019:2631713. View in: PubMed

  50. West AH, Knollman H, Dugan J, Hedeker D, Handorf EA, Nielsen SM, Bealin LC, Goldblatt LG, Willems H, Daly MB, Afghahi A, Olopade OI, Hulick PJ, Shagisultanova E, Huo D, Obeid E, Churpek JE. Hematologic toxicity in BRCA1 and BRCA2 mutation carriers during chemotherapy: A retrospective matched cohort study. Cancer Med. 2019 09; 8(12):5609-5618. View in: PubMed

  51. Yang MS, Hedeker D. A life-span approach to examining older vulnerable population's subjective well-being: the role of adversity and trauma. Aging Ment Health. 2020 12; 24(12):2043-2052. View in: PubMed

  52. Spears CA, Abroms LC, Glass CR, Hedeker D, Eriksen MP, Cottrell-Daniels C, Tran BQ, Wetter DW. Mindfulness-Based Smoking Cessation Enhanced With Mobile Technology (iQuit Mindfully): Pilot Randomized Controlled Trial. JMIR Mhealth Uhealth. 2019 06 24; 7(6):e13059. View in: PubMed

  53. Schepers ST, Arndt DL, Rogers RD, Hedeker D, de Wit H. Subjective responses to amphetamine in young adults with previous mood elevation experiences. Psychopharmacology (Berl). 2019 Nov; 236(11):3363-3370. View in: PubMed

  54. Reyes AC, Chaves R, Baxter-Jones ADG, Vasconcelos O, Barnett LM, Tani G, Hedeker D, Maia J. Modelling the dynamics of children's gross motor coordination. J Sports Sci. 2019 Oct; 37(19):2243-2252. View in: PubMed

  55. Pfammatter AF, Nahum-Shani I, DeZelar M, Scanlan L, McFadden HG, Siddique J, Hedeker D, Spring B. SMART: Study protocol for a sequential multiple assignment randomized controlled trial to optimize weight loss management. Contemp Clin Trials. 2019 07; 82:36-45. View in: PubMed

  56. Shiffman S, Scholl SM, Mao J, Ferguson SG, Hedeker D, Primack B, Tindle HA. Using Nicotine Gum to Assist Nondaily Smokers in Quitting: A Randomized Clinical Trial. Nicotine Tob Res. 2020 03 16; 22(3):390-397. View in: PubMed

  57. Maher JP, Dzubur E, Nordgren R, Huh J, Chou CP, Hedeker D, Dunton GF. Do fluctuations in positive affective and physical feeling states predict physical activity and sedentary time? Psychol Sport Exerc. 2019 Mar; 41:153-161. View in: PubMed

  58. Pereira S, Katzmarzyk PT, Gomes TN, Buranarugsa R, Moura-Dos-Santos MA, Hedeker D, Maia J. Sibling Similarity in Metabolic Syndrome: The Portuguese Sibling Study on Growth, Fitness, Lifestyle and Health. Behav Genet. 2019 05; 49(3):299-309. View in: PubMed

  59. Valdívia AB, Henrique RS, Pereira S, Chaves RN, Tani G, Freitas D, Prista A, Stodden DF, Katzmarzyk PT, Hedeker D, Maia J. Familial resemblance in gross motor coordination. The Peruvian Sibling Study on Growth and Health. Ann Hum Biol. 2018 Sep - Dec; 45(6-8):463-469. View in: PubMed

  60. Pereira S, Katzmarzyk PT, Hedeker D, Maia J. Profile Resemblance in Health-Related Markers: The Portuguese Sibling Study on Growth, Fitness, Lifestyle, and Health. Int J Environ Res Public Health. 2018 12 10; 15(12). View in: PubMed

  61. Rappaport LM, Russell JJ, Hedeker H, Pinard G, Bleau P, Moskowitz DS. Affect, interpersonal behaviour and interpersonal perception during open-label, uncontrolled paroxetine treatment of people with social anxiety disorder: a pilot study J Psychiatry Neurosci. 2018 11 01; 43(6):407-415. View in: PubMed

  62. Cursio JF, Mermelstein RJ, Hedeker D. Latent trait shared-parameter mixed models for missing ecological momentary assessment data. Stat Med. 2019 02 20; 38(4):660-673. View in: PubMed

  63. Rappaport LM, Russell JJ, Hedeker D, Pinard G, Bleau P, Moskowitz DS. Affect, interpersonal behaviour and interpersonal perception during open-label, uncontrolled paroxetine treatment of people with social anxiety disorder: a pilot study. J Psychiatry Neurosci. 2018 Aug 29; 43(6):170141. View in: PubMed

  64. Maher JP, Ra CK, Leventhal AM, Hedeker D, Huh J, Chou CP, Dunton GF. Mean level of positive affect moderates associations between volatility in positive affect, mental health, and alcohol consumption among mothers. J Abnorm Psychol. 2018 Oct; 127(7):639-649. View in: PubMed

  65. Xie H, Gao W, Xing B, Heitjan DF, Hedeker D, Yuan C. Measuring the Impact of Nonignorable Missingness Using the R Package isni. Comput Methods Programs Biomed. 2018 Oct; 164:207-220. View in: PubMed

  66. Courvoisier D, Walls TA, Cheval B, Hedeker D. A mixed-effects location scale model for time-to-event data: A smoking behavior application. Addict Behav. 2019 07; 94:42-49. View in: PubMed

  67. Wang J, Wang P, Hedeker D, Chen LS. Using multivariate mixed-effects selection models for analyzing batch-processed proteomics data with non-ignorable missingness. Biostatistics. 2019 10 01; 20(4):648-665. View in: PubMed

  68. Spring B, Pellegrini C, McFadden HG, Pfammatter AF, Stump TK, Siddique J, King AC, Hedeker D. Multicomponent mHealth Intervention for Large, Sustained Change in Multiple Diet and Activity Risk Behaviors: The Make Better Choices 2 Randomized Controlled Trial. J Med Internet Res. 2018 06 19; 20(6):e10528. View in: PubMed

  69. Selya AS, Cannon DS, Weiss RB, Wakschlag LS, Rose JS, Dierker L, Hedeker D, Mermelstein RJ. The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers. Addict Behav. 2018 09; 84:231-237. View in: PubMed

  70. Parker WF, Anderson AS, Hedeker D, Huang ES, Garrity ER, Siegler M, Churpek MM. Geographic Variation in the Treatment of U.S. Adult Heart Transplant Candidates. J Am Coll Cardiol. 2018 04 24; 71(16):1715-1725. View in: PubMed

  71. Antunes AM, Freitas DL, Maia J, Hedeker D, Gouveia ÉR, Thomis M, Lefevre J, Barnett LM. Motor performance, body fatness and environmental factors in preschool children. J Sports Sci. 2018 Oct; 36(20):2289-2295. View in: PubMed

  72. Lin X, Mermelstein RJ, Hedeker D. A 3-level Bayesian mixed effects location scale model with an application to ecological momentary assessment data. Stat Med. 2018 06 15; 37(13):2108-2119. View in: PubMed

  73. Gomes TN, Katzmarzyk PT, Hedeker D, Fogelholm M, Standage M, Onywera V, Lambert EV, Tremblay MS, Chaput JP, Tudor-Locke C, Sarmiento O, Matsudo V, Kurpad A, Kuriyan R, Zhao P, Hu G, Olds T, Maher C, Maia J. Correlates of compliance with recommended levels of physical activity in children. Sci Rep. 2017 11 28; 7(1):16507. View in: PubMed

  74. Selya AS, Dierker L, Rose JS, Hedeker D, Mermelstein RJ. The Role of Nicotine Dependence in E-Cigarettes' Potential for Smoking Reduction. Nicotine Tob Res. 2018 09 04; 20(10):1272-1277. View in: PubMed

  75. Pereira S, Katzmarzyk PT, Gomes TN, Souza M, Chaves RN, Santos FK, Santos D, Bustamante A, Barreira TV, Hedeker D, Maia JA. Resemblance in physical activity levels: The Portuguese sibling study on growth, fitness, lifestyle, and health. Am J Hum Biol. 2018 01; 30(1). View in: PubMed

  76. Chen LX, Josephson MA, Hedeker D, Campbell KH, Stankus N, Saunders MR. A Clinical Prediction Score to Guide Referral of Elderly Dialysis Patients for Kidney Transplant Evaluation. Kidney Int Rep. 2017 Jul; 2(4):645-653. View in: PubMed

  77. Adegunsoye A, Oldham JM, Fernández Pérez ER, Hamblin M, Patel N, Tener M, Bhanot D, Robinson L, Bullick S, Chen L, Hsu S, Churpek M, Hedeker D, Montner S, Chung JH, Husain AN, Noth I, Strek ME, Vij R. Outcomes of immunosuppressive therapy in chronic hypersensitivity pneumonitis. ERJ Open Res. 2017 Jul; 3(3). View in: PubMed

  78. Selya AS, Rose JS, Dierker L, Hedeker D, Mermelstein RJ. Evaluating the mutual pathways among electronic cigarette use, conventional smoking and nicotine dependence. Addiction. 2018 02; 113(2):325-333. View in: PubMed

  79. Freitas D, Maia J, Stasinopoulos M, Gouveia ÉR, Antunes AM, Thomis M, Lefevre J, Claessens A, Hedeker D, Malina RM. Biological and environmental determinants of 12-minute run performance in youth. Ann Hum Biol. 2017 Nov; 44(7):607-613. View in: PubMed

  80. Weafer J, Lyon N, Hedeker D, de Wit H. Sweet taste liking is associated with subjective response to amphetamine in women but not men. Psychopharmacology (Berl). 2017 Nov; 234(21):3185-3194. View in: PubMed

  81. Wray CM, Arora VM, Hedeker D, Meltzer DO. Assessing the implementation of a bedside service handoff on an academic hospitalist service. Healthc (Amst). 2018 Jun; 6(2):117-121. View in: PubMed

  82. Spears CA, Hedeker D, Li L, Wu C, Anderson NK, Houchins SC, Vinci C, Hoover DS, Vidrine JI, Cinciripini PM, Waters AJ, Wetter DW. Mechanisms underlying mindfulness-based addiction treatment versus cognitive behavioral therapy and usual care for smoking cessation. J Consult Clin Psychol. 2017 Nov; 85(11):1029-1040. View in: PubMed

  83. Spring B, Pellegrini CA, Pfammatter A, Duncan JM, Pictor A, McFadden HG, Siddique J, Hedeker D. Effects of an abbreviated obesity intervention supported by mobile technology: The ENGAGED randomized clinical trial. Obesity (Silver Spring). 2017 07; 25(7):1191-1198. View in: PubMed

  84. Hedeker D, du Toit SHC, Demirtas H, Gibbons RD. A note on marginalization of regression parameters from mixed models of binary outcomes. Biometrics. 2018 03; 74(1):354-361. View in: PubMed

  85. Weafer J, Gorka SM, Hedeker D, Dzemidzic M, Kareken DA, Phan KL, de Wit H. Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity. Neuropsychopharmacology. 2017 Aug; 42(9):1905-1913. View in: PubMed

  86. Villanti AC, Johnson AL, Rath JM, Williams V, Vallone DM, Abrams DB, Hedeker D, Mermelstein RJ. Identifying "social smoking" U.S. young adults using an empirically-driven approach. Addict Behav. 2017 07; 70:83-89. View in: PubMed

  87. Gorka SM, Hedeker D, Piasecki TM, Mermelstein R. Impact of alcohol use motives and internalizing symptoms on mood changes in response to drinking: An ecological momentary assessment investigation. Drug Alcohol Depend. 2017 Apr 01; 173:31-38. View in: PubMed

  88. Pereira S, Todd Katzmarzyk P, Gomes TN, Souza M, Chaves RN, Dos Santos FK, Santos D, Hedeker D, Maia J. A multilevel analysis of health-related physical fitness. The Portuguese sibling study on growth, fitness, lifestyle and health. PLoS One. 2017; 12(2):e0172013. View in: PubMed

  89. Gomes TN, Hedeker D, Dos Santos FK, Souza M, Santos D, Pereira S, Katzmarzyk PT, Maia J. Relationship between Sedentariness and Moderate-to-Vigorous Physical Activity in Youth: A Multivariate Multilevel Study. Int J Environ Res Public Health. 2017 02 04; 14(2). View in: PubMed

  90. Piotrowski ZH, Hedeker D. Evaluation of the Be the Exception Sixth-Grade Program in Rural Communities to Delay the Onset of Sexual Behavior. Am J Public Health. 2016 Sep; 106(S1):S132-S139. View in: PubMed

  91. Pereira S, Katzmarzyk PT, Gomes TN, Souza M, Chaves RN, Santos FKD, Santos D, Hedeker D, Maia JAR. Multilevel modelling of somatotype components: the Portuguese sibling study on growth, fitness, lifestyle and health. Ann Hum Biol. 2017 Jun; 44(4):316-324. View in: PubMed

  92. Conroy DE, Hedeker D, McFadden HG, Pellegrini CA, Pfammatter AF, Phillips SM, Siddique J, Spring B. Lifestyle intervention effects on the frequency and duration of daily moderate-vigorous physical activity and leisure screen time. Health Psychol. 2017 Apr; 36(4):299-308. View in: PubMed

  93. Pugach O, Cannon DS, Weiss RB, Hedeker D, Mermelstein RJ. Classification Tree Analysis as a Method for Uncovering Relations Between CHRNA5A3B4 and CHRNB3A6 in Predicting Smoking Progression in Adolescent Smokers. Nicotine Tob Res. 2017 Apr 01; 19(4):410-416. View in: PubMed

  94. Dierker L, Selya A, Rose J, Hedeker D, Mermelstein R. Nicotine Dependence and Alcohol Problems from Adolescence to Young Adulthood. Dual Diagn (Foster City). 2016; 1(2). View in: PubMed

  95. Hedeker D, Mermelstein RJ, Demirtas H, Berbaum ML. A Mixed-effects Location-Scale Model for Ordinal Questionnaire Data. Health Serv Outcomes Res Methodol. 2016 Sep; 16(3):117-131. View in: PubMed

  96. Padula WV, Gibbons RD, Pronovost PJ, Hedeker D, Mishra MK, Makic MB, Bridges JF, Wald HL, Valuck RJ, Ginensky AJ, Ursitti A, Venable LR, Epstein Z, Meltzer DO. Using clinical data to predict high-cost performance coding issues associated with pressure ulcers: a multilevel cohort model. J Am Med Inform Assoc. 2017 Apr 01; 24(e1):e95-e102. View in: PubMed

  97. Gao W, Hedeker D, Mermelstein R, Xie H. A scalable approach to measuring the impact of nonignorable nonresponse with an EMA application. Stat Med. 2016 12 30; 35(30):5579-5602. View in: PubMed

  98. Pfammatter A, Spring B, Saligram N, Davé R, Gowda A, Blais L, Arora M, Ranjani H, Ganda O, Hedeker D, Reddy S, Ramalingam S. mHealth Intervention to Improve Diabetes Risk Behaviors in India: A Prospective, Parallel Group Cohort Study. J Med Internet Res. 2016 08 05; 18(8):e207. View in: PubMed

  99. Selya AS, Dierker L, Rose JS, Hedeker D, Mermelstein RJ. Early-Emerging Nicotine Dependence Has Lasting and Time-Varying Effects on Adolescent Smoking Behavior. Prev Sci. 2016 08; 17(6):743-50. View in: PubMed

  100. Capuano AW, Wilson RS, Leurgans SE, Dawson JD, Bennett DA, Hedeker D. Sigmoidal mixed models for longitudinal data. Stat Methods Med Res. 2018 03; 27(3):863-875. View in: PubMed

  101. Schneider KL, Coons MJ, McFadden HG, Pellegrini CA, DeMott A, Siddique J, Hedeker D, Aylward L, Spring B. Mechanisms of Change in Diet and Activity in the Make Better Choices 1 Trial. Health Psychol. 2016 Apr 07. View in: PubMed

  102. Pereira S, Borges A, Gomes TN, Santos D, Souza M, Dos Santos FK, Chaves RN, Barreira TV, Hedeker D, Katzmarzyk PT, Maia JAR. Correlates of children's compliance with moderate-to-vigorous physical activity recommendations: a multilevel analysis. Scand J Med Sci Sports. 2017 Aug; 27(8):842-851. View in: PubMed

  103. Piasecki TM, Hedeker D, Dierker LC, Mermelstein RJ. Progression of nicotine dependence, mood level, and mood variability in adolescent smokers. Psychol Addict Behav. 2016 06; 30(4):484-93. View in: PubMed

  104. Ong JC, Hedeker D, Wyatt JK, Manber R. Examining the Variability of Sleep Patterns during Treatment for Chronic Insomnia: Application of a Location-Scale Mixed Model. J Clin Sleep Med. 2016 06 15; 12(6):797-804. View in: PubMed

  105. Schuster RM, Mermelstein RJ, Hedeker D. Ecological momentary assessment of working memory under conditions of simultaneous marijuana and tobacco use. Addiction. 2016 08; 111(8):1466-76. View in: PubMed

  106. Cannon DS, Mermelstein RJ, Medina TR, Pugach O, Hedeker D, Weiss RB. CYP2A6 Effects on Subjective Reactions to Initial Smoking Attempt. Nicotine Tob Res. 2016 May; 18(5):637-41. View in: PubMed

  107. Cafri G, Hedeker D, Aarons GA. An introduction and integration of cross-classified, multiple membership, and dynamic group random-effects models. Psychol Methods. 2015 Dec; 20(4):407-21. View in: PubMed

  108. Gomes TN, Hedeker D, dos Santos FK, Pereira S, Katzmarzyk PT, Maia JA. Why Are Children Different in Their Daily Sedentariness? An Approach Based on the Mixed-Effects Location Scale Model. PLoS One. 2015; 10(7):e0132192. View in: PubMed

  109. Gomes TN, Katzmarzyk PT, dos Santos FK, de Chaves RN, Santos D, Pereira S, Champagne CM, Hedeker D, Maia J. Are BMI and Sedentariness Correlated? A Multilevel Study in Children. Nutrients. 2015 Jul 16; 7(7):5889-904. View in: PubMed

  110. Schuster RM, Mermelstein RJ, Hedeker D. Acceptability and feasibility of a visual working memory task in an ecological momentary assessment paradigm. Psychol Assess. 2015 Dec; 27(4):1463-70. View in: PubMed

  111. McGinley JS, Curran PJ, Hedeker D. A novel modeling framework for ordinal data defined by collapsed counts. Stat Med. 2015 Jul 10; 34(15):2312-24. View in: PubMed

  112. Dierker L, Hedeker D, Rose J, Selya A, Mermelstein R. Early emerging nicotine dependence symptoms in adolescence predict daily smoking in young adulthood. Drug Alcohol Depend. 2015 Jun 01; 151:267-71. View in: PubMed

  113. Passarotti AM, Crane NA, Hedeker D, Mermelstein RJ. Longitudinal trajectories of marijuana use from adolescence to young adulthood. Addict Behav. 2015 Jun; 45:301-8. View in: PubMed

  114. Cannon DS, Medina TR, Mermelstein RJ, Hedeker D, Bakian AV, Coon H, Cook EH, Hamil C, Weiss RB. CYP2A6 Longitudinal Effects in Young Smokers. Nicotine Tob Res. 2016 Feb; 18(2):196-203. View in: PubMed

  115. Pellegrini CA, Steglitz J, Johnston W, Warnick J, Adams T, McFadden HG, Siddique J, Hedeker D, Spring B. Design and protocol of a randomized multiple behavior change trial: Make Better Choices 2 (MBC2). Contemp Clin Trials. 2015 Mar; 41:85-92. View in: PubMed

  116. Pugach O, Hedeker D, Mermelstein R. A Bivariate Mixed-Effects Location-Scale Model with application to Ecological Momentary Assessment (EMA) data. Health Serv Outcomes Res Methodol. 2014 Dec; 14(4):194-212. View in: PubMed

  117. Krzak JJ, Corcos DM, Damiano DL, Graf A, Hedeker D, Smith PA, Harris GF. Kinematic foot types in youth with equinovarus secondary to hemiplegia. Gait Posture. 2015 Feb; 41(2):402-8. View in: PubMed

  118. Dierker L, Rose J, Selya A, Piasecki TM, Hedeker D, Mermelstein R. Depression and nicotine dependence from adolescence to young adulthood. Addict Behav. 2015 Feb; 41:124-8. View in: PubMed

  119. Kapur K, Li X, Blood EA, Hedeker D. Bayesian mixed-effects location and scale models for multivariate longitudinal outcomes: an application to ecological momentary assessment data. Stat Med. 2015 Feb 20; 34(4):630-51. View in: PubMed

  120. Nadell MJ, Mermelstein RJ, Hedeker D, Marquez DX. Work and Non-Work Physical Activity Predict Real-Time Smoking Level and Urges in Young Adults. Nicotine Tob Res. 2015 Jul; 17(7):803-9. View in: PubMed

  121. Selya AS, Updegrove N, Rose JS, Dierker L, Tan X, Hedeker D, Li R, Mermelstein RJ. Nicotine-dependence-varying effects of smoking events on momentary mood changes among adolescents. Addict Behav. 2015 Feb; 41:65-71. View in: PubMed

  122. Raghavan R, Brown DS, Allaire BT, Garfield LD, Ross RE, Hedeker D. Challenges in using medicaid claims to ascertain child maltreatment. Child Maltreat. 2015 May; 20(2):83-91. View in: PubMed

  123. Hedeker D. Methods for Multilevel Ordinal Data in Prevention Research. Prev Sci. 2015 Oct; 16(7):997-1006. View in: PubMed

  124. Huh J, Shin H, Leventhal AM, Spruijt-Metz D, Abramova Z, Cerrada C, Hedeker D, Dunton G. Momentary negative moods and being with friends precede cigarette use among Korean American emerging adults. Nicotine Tob Res. 2014 Sep; 16(9):1248-54. View in: PubMed

  125. Siddique J, Harel O, Crespi CM, Hedeker D. Binary variable multiple-model multiple imputation to address missing data mechanism uncertainty: application to a smoking cessation trial. Stat Med. 2014 Jul 30; 33(17):3013-28. View in: PubMed

  126. Smith-Ray RL, Hughes SL, Prohaska TR, Little DM, Jurivich DA, Hedeker D. Impact of Cognitive Training on Balance and Gait in Older Adults. J Gerontol B Psychol Sci Soc Sci. 2015 May; 70(3):357-66. View in: PubMed

  127. Moller AC, Buscemi J, McFadden HG, Hedeker D, Spring B. Financial motivation undermines potential enjoyment in an intensive diet and activity intervention. J Behav Med. 2014 Oct; 37(5):819-27. View in: PubMed

  128. Sokolovsky AW, Mermelstein RJ, Hedeker D. Factors predicting compliance to ecological momentary assessment among adolescent smokers. Nicotine Tob Res. 2014 Mar; 16(3):351-8. View in: PubMed

  129. Pugach O, Hedeker D, Richmond MJ, Sokolovsky A, Mermelstein R. Modeling mood variation and covariation among adolescent smokers: application of a bivariate location-scale mixed-effects model. Nicotine Tob Res. 2014 May; 16 Suppl 2:S151-8. View in: PubMed

  130. Piasecki TM, Trela CJ, Hedeker D, Mermelstein RJ. Smoking antecedents: separating between- and within-person effects of tobacco dependence in a multiwave ecological momentary assessment investigation of adolescent smoking. Nicotine Tob Res. 2014 May; 16 Suppl 2:S119-26. View in: PubMed

  131. Cannon DS, Mermelstein RJ, Hedeker D, Coon H, Cook EH, McMahon WM, Hamil C, Dunn D, Weiss RB. Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults. Nicotine Tob Res. 2014 Feb; 16(2):137-44. View in: PubMed

  132. Abdollahi F, Case Lazarro ED, Listenberger M, Kenyon RV, Kovic M, Bogey RA, Hedeker D, Jovanovic BD, Patton JL. Error augmentation enhancing arm recovery in individuals with chronic stroke: a randomized crossover design. Neurorehabil Neural Repair. 2014 Feb; 28(2):120-8. View in: PubMed

  133. Kumar S, Nilsen WJ, Abernethy A, Atienza A, Patrick K, Pavel M, Riley WT, Shar A, Spring B, Spruijt-Metz D, Hedeker D, Honavar V, Kravitz R, Lefebvre RC, Mohr DC, Murphy SA, Quinn C, Shusterman V, Swendeman D. Mobile health technology evaluation: the mHealth evidence workshop. Am J Prev Med. 2013 Aug; 45(2):228-36. View in: PubMed

  134. Mehta SD, Moses S, Agot K, Odoyo-June E, Li H, Maclean I, Hedeker D, Bailey RC. The long-term efficacy of medical male circumcision against HIV acquisition. AIDS. 2013 Nov 28; 27(18):2899-907. View in: PubMed

  135. Leon AC, Demirtas H, Li C, Hedeker D. Subject-level matching for imbalance in cluster randomized trials with a small number of clusters. Pharm Stat. 2013 Sep-Oct; 12(5):268-74. View in: PubMed

  136. Selya AS, Wakschlag LS, Dierker LC, Rose JS, Hedeker D, Mermelstein RJ. Exploring alternate processes contributing to the association between maternal smoking and the smoking behavior among young adult offspring. Nicotine Tob Res. 2013 Nov; 15(11):1873-82. View in: PubMed

  137. Hedeker D, Nordgren R. MIXREGLS: A Program for Mixed-Effects Location Scale Analysis. J Stat Softw. 2013 Mar; 52(12):1-38. View in: PubMed

  138. Dunton GF, Huh J, Leventhal AM, Riggs N, Hedeker D, Spruijt-Metz D, Pentz MA. Momentary assessment of affect, physical feeling states, and physical activity in children. Health Psychol. 2014 Mar; 33(3):255-63. View in: PubMed

  139. Spring B, Duncan JM, Janke EA, Kozak AT, McFadden HG, DeMott A, Pictor A, Epstein LH, Siddique J, Pellegrini CA, Buscemi J, Hedeker D. Integrating technology into standard weight loss treatment: a randomized controlled trial. JAMA Intern Med. 2013 Jan 28; 173(2):105-11. View in: PubMed

  140. Rose JS, Dierker LC, Hedeker D, Mermelstein R. An integrated data analysis approach to investigating measurement equivalence of DSM nicotine dependence symptoms. Drug Alcohol Depend. 2013 Apr 01; 129(1-2):25-32. View in: PubMed

  141. Selya AS, Dierker LC, Rose JS, Hedeker D, Tan X, Li R, Mermelstein RJ. Time-varying effects of smoking quantity and nicotine dependence on adolescent smoking regularity. Drug Alcohol Depend. 2013 Mar 01; 128(3):230-7. View in: PubMed

  142. Li X, Hedeker D. A three-level mixed-effects location scale model with an application to ecological momentary assessment data. Stat Med. 2012 Nov 20; 31(26):3192-210. View in: PubMed

  143. Leon AC, Demirtas H, Li C, Hedeker D. Two propensity score-based strategies for a three-decade observational study: investigating psychotropic medications and suicide risk. Stat Med. 2012 Nov 30; 31(27):3255-60. View in: PubMed

  144. Hedeker D, Demirtas H, Gibbons RD. Andrew C. Leon, Ph.D. (1951-2012). Stat Med. 2012 Nov 30; 31(27):3253-4. View in: PubMed

  145. Spring B, Schneider K, McFadden HG, Vaughn J, Kozak AT, Smith M, Moller AC, Epstein LH, Demott A, Hedeker D, Siddique J, Lloyd-Jones DM. Multiple behavior changes in diet and activity: a randomized controlled trial using mobile technology. Arch Intern Med. 2012 May 28; 172(10):789-96. View in: PubMed

  146. Liu LC, Hedeker D, Mermelstein RJ. Modeling nicotine dependence: an application of a longitudinal IRT model for the analysis of adolescent nicotine dependence syndrome scale. Nicotine Tob Res. 2013 Feb; 15(2):326-33. View in: PubMed

  147. Moller AC, McFadden HG, Hedeker D, Spring B. Financial motivation undermines maintenance in an intensive diet and activity intervention. J Obes. 2012; 2012:740519. View in: PubMed

  148. Demirtas H, Hedeker D, Mermelstein RJ. Simulation of massive public health data by power polynomials. Stat Med. 2012 Nov 30; 31(27):3337-46. View in: PubMed

  149. Selya AS, Rose JS, Dierker LC, Hedeker D, Mermelstein RJ. A Practical Guide to Calculating Cohen's f(2), a Measure of Local Effect Size, from PROC MIXED. Front Psychol. 2012; 3:111. View in: PubMed

  150. Leon AC, Hedeker D, Li C, Demirtas H. Performance of a propensity score adjustment in longitudinal studies with covariate-dependent representation. Stat Med. 2012 Sep 10; 31(20):2262-74. View in: PubMed

  151. Hedeker D, Mermelstein RJ, Demirtas H. Modeling between-subject and within-subject variances in ecological momentary assessment data using mixed-effects location scale models. Stat Med. 2012 Nov 30; 31(27):3328-36. View in: PubMed

  152. Selya AS, Dierker LC, Rose JS, Hedeker D, Mermelstein RJ. Risk factors for adolescent smoking: parental smoking and the mediating role of nicotine dependence. Drug Alcohol Depend. 2012 Aug 01; 124(3):311-8. View in: PubMed

  153. Liu FX, Alexander GC, Crawford SY, Pickard AS, Hedeker D, Walton SM. The impact of Medicare Part D on out-of-pocket costs for prescription drugs, medication utilization, health resource utilization, and preference-based health utility. Health Serv Res. 2011 Aug; 46(4):1104-23. View in: PubMed

  154. Duncan JM, Janke EA, Kozak AT, Roehrig M, Russell SW, McFadden HG, Demott A, Pictor A, Hedeker D, Spring B. PDA+: A Personal Digital Assistant for Obesity Treatment - an RCT testing the use of technology to enhance weight loss treatment for veterans. BMC Public Health. 2011 Apr 11; 11:223. View in: PubMed

  155. Spring B, Schneider K, McFadden HG, Vaughn J, Kozak AT, Smith M, Moller AC, Epstein L, Russell SW, DeMott A, Hedeker D. Make Better Choices (MBC): study design of a randomized controlled trial testing optimal technology-supported change in multiple diet and physical activity risk behaviors. BMC Public Health. 2010 Sep 29; 10:586. View in: PubMed

  156. Hedeker D, Demirtas H, Mermelstein RJ. A mixed ordinal location scale model for analysis of Ecological Momentary Assessment (EMA) data. Stat Interface. 2009; 2(4):391-401. View in: PubMed

  157. Gibbons RD, Hedeker D, DuToit S. Advances in analysis of longitudinal data. Annu Rev Clin Psychol. 2010; 6:79-107. View in: PubMed

  158. Muramatsu N, Yin H, Hedeker D. Functional declines, social support, and mental health in the elderly: does living in a state supportive of home and community-based services make a difference? Soc Sci Med. 2010 Apr; 70(7):1050-8. View in: PubMed

  159. Schneider KL, Hedeker D, Bailey KC, Cook JW, Spring B. A comment on analyzing addictive behaviors over time. Nicotine Tob Res. 2010 Apr; 12(4):445-8. View in: PubMed

  160. Siddique J, Brown CH, Hedeker D, Duan N, Gibbons RD, Miranda J, Lavori PW. Missing Data in Longitudinal Trials - Part B, Analytic Issues. Psychiatr Ann. 2008 Dec 01; 38(12):793-801. View in: PubMed

  161. Friedman LS, Hedeker D, Richter ED. Long-term effects of repealing the national maximum speed limit in the United States. Am J Public Health. 2009 Sep; 99(9):1626-31. View in: PubMed

  162. Pagoto SL, Kozak AT, John P, Bodenlos JS, Hedeker D, Spring B, Schneider KL. Intention-to-treat analyses in behavioral medicine randomized clinical trials. Int J Behav Med. 2009; 16(4):316-22. View in: PubMed

  163. Pagoto SL, Spring B, McChargue D, Hitsman B, Smith M, Appelhans B, Hedeker D. Acute tryptophan depletion and sweet food consumption by overweight adults. Eat Behav. 2009 Jan; 10(1):36-41. View in: PubMed

  164. Hedeker D, Mermelstein RJ, Berbaum ML, Campbell RT. Modeling mood variation associated with smoking: an application of a heterogeneous mixed-effects model for analysis of ecological momentary assessment (EMA) data. Addiction. 2009 Feb; 104(2):297-307. View in: PubMed

  165. Colder CR, Flay BR, Segawa E, Hedeker D. Trajectories of smoking among freshmen college students with prior smoking history and risk for future smoking: data from the University Project Tobacco Etiology Research Network (UpTERN) study. Addiction. 2008 Sep; 103(9):1534-43. View in: PubMed

  166. Weinstein SM, Mermelstein RJ, Hankin BL, Hedeker D, Flay BR. Longitudinal Patterns of Daily Affect and Global Mood During Adolescence. J Res Adolesc. 2007 Sep; 17(3):587-600. View in: PubMed

  167. Hedeker D, Mermelstein RJ, Weeks KA. The thresholds of change model: an approach to analyzing stages of change data. Ann Behav Med. 1999; 21(1):61-70. View in: PubMed

  168. Demirtas H, Hedeker D. An imputation strategy for incomplete longitudinal ordinal data. Stat Med. 2008 Sep 10; 27(20):4086-93. View in: PubMed

  169. Spring B, Schneider K, Smith M, Kendzor D, Appelhans B, Hedeker D, Pagoto S. Abuse potential of carbohydrates for overweight carbohydrate cravers. Psychopharmacology (Berl). 2008 May; 197(4):637-47. View in: PubMed

  170. Leon AC, Hedeker D. Quantile Stratification Based on a Misspecified Propensity Score in Longitudinal Treatment Effectiveness Analyses of Ordinal Doses. Comput Stat Data Anal. 2007 Aug 15; 51(12):6114-6122. View in: PubMed

  171. Hedeker D, Mermelstein RJ, Demirtas H. An application of a mixed-effects location scale model for analysis of Ecological Momentary Assessment (EMA) data. Biometrics. 2008 Jun; 64(2):627-34. View in: PubMed

  172. Spring B, Cook JW, Appelhans B, Maloney A, Richmond M, Vaughn J, Vanderveen J, Hedeker D. Nicotine effects on affective response in depression-prone smokers. Psychopharmacology (Berl). 2008 Feb; 196(3):461-71. View in: PubMed

  173. Leon AC, Demirtas H, Hedeker D. Bias reduction with an adjustment for participants' intent to dropout of a randomized controlled clinical trial. Clin Trials. 2007; 4(5):540-7. View in: PubMed

  174. Hedeker D, Mermelstein RJ, Demirtas H. Analysis of binary outcomes with missing data: missing = smoking, last observation carried forward, and a little multiple imputation. Addiction. 2007 Oct; 102(10):1564-73. View in: PubMed

  175. Hitsman B, Spring B, Pingitore R, Munafò M, Hedeker D. Effect of tryptophan depletion on the attentional salience of smoking cues. Psychopharmacology (Berl). 2007 Jun; 192(3):317-24. View in: PubMed

  176. Spring B, Doran N, Pagoto S, McChargue D, Cook JW, Bailey K, Crayton J, Hedeker D. Fluoxetine, smoking, and history of major depression: A randomized controlled trial. J Consult Clin Psychol. 2007 Feb; 75(1):85-94. View in: PubMed

  177. Lacey SE, Conroy L, Schoonover T, Franke J, Hedeker D, Forst L. Dust emission rates from food processing. Ann Agric Environ Med. 2006; 13(2):251-7. View in: PubMed

  178. Schulze TG, Hedeker D, Zandi P, Rietschel M, McMahon FJ. What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics. Arch Gen Psychiatry. 2006 Dec; 63(12):1368-76. View in: PubMed

  179. Spring B, Pagoto S, Knatterud G, Kozak A, Hedeker D. Examination of the analytic quality of behavioral health randomized clinical trials. J Clin Psychol. 2007 Jan; 63(1):53-71. View in: PubMed

  180. Leon AC, Hedeker D. A comparison of mixed-effects quantile stratification propensity adjustment strategies for longitudinal treatment effectiveness analyses of continuous outcomes. Stat Med. 2007 Jun 15; 26(13):2650-65. View in: PubMed

  181. Kassem L, Lopez V, Hedeker D, Steele J, Zandi P. Familiality of polarity at illness onset in bipolar affective disorder. Am J Psychiatry. 2006 Oct; 163(10):1754-9. View in: PubMed

  182. Cambron JA, Gudavalli MR, Hedeker D, McGregor M, Jedlicka J, Keenum M, Ghanayem AJ, Patwardhan AG, Furner SE. One-year follow-up of a randomized clinical trial comparing flexion distraction with an exercise program for chronic low-back pain. J Altern Complement Med. 2006 Sep; 12(7):659-68. View in: PubMed

  183. Lacey SE, Conroy LM, Forst LS, Franke JE, Wadden RA, Hedeker DR. Personal dust exposures at a food processing facility. J Agromedicine. 2006; 11(1):49-58. View in: PubMed

  184. Spring B, Hitsman B, Pingitore R, McChargue DE, Gunnarsdottir D, Corsica J, Pergadia M, Doran N, Crayton JW, Baruah S, Hedeker D. Effect of tryptophan depletion on smokers and nonsmokers with and without history of major depression. Biol Psychiatry. 2007 Jan 01; 61(1):70-7. View in: PubMed

  185. Weinstein SM, Mermelstein RJ, Hedeker D, Hankin BL, Flay BR. The time-varying influences of peer and family support on adolescent daily positive and negative affect. J Clin Child Adolesc Psychol. 2006 Sep; 35(3):420-30. View in: PubMed

  186. Colder CR, Lloyd-Richardson EE, Flaherty BP, Hedeker D, Segawa E, Flay BR. The natural history of college smoking: trajectories of daily smoking during the freshman year. Addict Behav. 2006 Dec; 31(12):2212-22. View in: PubMed

  187. Demirtas H, Hedeker D. Gaussianization-based quasi-imputation and expansion strategies for incomplete correlated binary responses. Stat Med. 2007 Feb 20; 26(4):782-99. View in: PubMed

  188. Liu LC, Hedeker D. A mixed-effects regression model for longitudinal multivariate ordinal data. Biometrics. 2006 Mar; 62(1):261-8. View in: PubMed

  189. Doran N, Spring B, Borrelli B, McChargue D, Hitsman B, Niaura R, Hedeker D. Elevated positive mood: a mixed blessing for abstinence. Psychol Addict Behav. 2006 Mar; 20(1):36-43. View in: PubMed

  190. Leon AC, Hedeker D, Teres JJ. Bias reduction in effectiveness analyses of longitudinal ordinal doses with a mixed-effects propensity adjustment. Stat Med. 2007 Jan 15; 26(1):110-23. View in: PubMed

  191. Raman R, Hedeker D. A mixed-effects regression model for three-level ordinal response data. Stat Med. 2005 Nov 15; 24(21):3331-45. View in: PubMed

  192. Wang Y, Tussing L, Odoms-Young A, Braunschweig C, Flay B, Hedeker D, Hellison D. Obesity prevention in low socioeconomic status urban African-american adolescents: study design and preliminary findings of the HEALTH-KIDS Study. Eur J Clin Nutr. 2006 Jan; 60(1):92-103. View in: PubMed

  193. Persky I, Spring B, Vander Wal JS, Pagoto S, Hedeker D. Adherence across behavioral domains in treatment promoting smoking cessation plus weight control. Health Psychol. 2005 Mar; 24(2):153-60. View in: PubMed

  194. Leon AC, Hedeker D. A mixed-effects quintile-stratified propensity adjustment for effectiveness analyses of ordered categorical doses. Stat Med. 2005 Feb 28; 24(4):647-58. View in: PubMed

  195. Hitsman B, Spring B, Wolf W, Pingitore R, Crayton JW, Hedeker D. Effects of acute tryptophan depletion on negative symptoms and smoking topography in nicotine-dependent schizophrenics and nonpsychiatric controls. Neuropsychopharmacology. 2005 Mar; 30(3):640-8. View in: PubMed

  196. Spring B, Pagoto S, Pingitore R, Doran N, Schneider K, Hedeker D. Randomized controlled trial for behavioral smoking and weight control treatment: effect of concurrent versus sequential intervention. J Consult Clin Psychol. 2004 Oct; 72(5):785-96. View in: PubMed

  197. Cook JW, Spring B, McChargue D, Hedeker D. Hedonic capacity, cigarette craving, and diminished positive mood. Nicotine Tob Res. 2004 Feb; 6(1):39-47. View in: PubMed

  198. Fischer ME, Vitek ME, Hedeker D, Henderson WG, Jacobsen SJ, Goldberg J. A twin study of erectile dysfunction. Arch Intern Med. 2004 Jan 26; 164(2):165-8. View in: PubMed

  199. Spring B, Pagoto S, McChargue D, Hedeker D, Werth J. Altered reward value of carbohydrate snacks for female smokers withdrawn from nicotine. Pharmacol Biochem Behav. 2003 Sep; 76(2):351-60. View in: PubMed

  200. Mermelstein R, Hedeker D, Wong SC. Extended telephone counseling for smoking cessation: does content matter? J Consult Clin Psychol. 2003 Jun; 71(3):565-74. View in: PubMed

  201. Hedeker D. A mixed-effects multinomial logistic regression model. Stat Med. 2003 May 15; 22(9):1433-46. View in: PubMed

  202. Niaura R, Spring B, Borrelli B, Hedeker D, Goldstein MG, Keuthen N, DePue J, Kristeller J, Ockene J, Prochazka A, Chiles JA, Abrams DB. Multicenter trial of fluoxetine as an adjunct to behavioral smoking cessation treatment. J Consult Clin Psychol. 2002 Aug; 70(4):887-96. View in: PubMed

  203. Xie H, McHugo G, Sengupta A, Hedeker D, Drake R. An application of the thresholds of change model to the analysis of mental health data. Ment Health Serv Res. 2001 Jun; 3(2):107-14. View in: PubMed

  204. Xu W, Hedeker D. A random-effects mixture model for classifying treatment response in longitudinal clinical trials. J Biopharm Stat. 2001 Nov; 11(4):253-73. View in: PubMed

  205. Campbell SK, Hedeker D. Validity of the Test of Infant Motor Performance for discriminating among infants with varying risk for poor motor outcome. J Pediatr. 2001 Oct; 139(4):546-51. View in: PubMed

  206. Altman E, Hedeker D, Peterson JL, Davis JM. A comparative evaluation of three self-rating scales for acute mania. Biol Psychiatry. 2001 Sep 15; 50(6):468-71. View in: PubMed

  207. Hall SM, Delucchi KL, Velicer WF, Kahler CW, Ranger-Moore J, Hedeker D, Tsoh JY, Niaura R. Statistical analysis of randomized trials in tobacco treatment: longitudinal designs with dichotomous outcome. Nicotine Tob Res. 2001 Aug; 3(3):193-202. View in: PubMed

  208. Hedeker D, Mermelstein RJ. Analysis of longitudinal substance use outcomes using ordinal random-effects regression models. Addiction. 2000 Nov; 95 Suppl 3:S381-94. View in: PubMed

  209. Hedeker D, Siddiqui O, Hu FB. Random-effects regression analysis of correlated grouped-time survival data. Stat Methods Med Res. 2000 Apr; 9(2):161-79. View in: PubMed

  210. Jason LA, Salina D, McMahon SD, Hedeker D, Stockton M. A worksite smoking intervention: a 2 year assessment of groups, incentives and self-help. Health Educ Res. 1997 Mar; 12(1):129-38. View in: PubMed

  211. Hu FB, Goldberg J, Hedeker D, Henderson WG. Modelling ordinal responses from co-twin control studies. Stat Med. 1998 May 15; 17(9):957-70. View in: PubMed

  212. Hu FB, Goldberg J, Hedeker D, Flay BR, Pentz MA. Comparison of population-averaged and subject-specific approaches for analyzing repeated binary outcomes. Am J Epidemiol. 1998 Apr 01; 147(7):694-703. View in: PubMed

  213. Gibbons RD, Hedeker D. Random effects probit and logistic regression models for three-level data. Biometrics. 1997 Dec; 53(4):1527-37. View in: PubMed

  214. Altman EG, Hedeker D, Peterson JL, Davis JM. The Altman Self-Rating Mania Scale. Biol Psychiatry. 1997 Nov 15; 42(10):948-55. View in: PubMed

  215. Goldman MB, Robertson GL, Luchins DJ, Hedeker D, Pandey GN. Psychotic exacerbations and enhanced vasopressin secretion in schizophrenic patients with hyponatremia and polydipsia. Arch Gen Psychiatry. 1997 May; 54(5):443-9. View in: PubMed

  216. Hu FB, Hedeker D, Day LE, Flay BR, Siddiqui O, Sussman S, Richardson J. Patterns of use of smokeless tobacco and the unidimensional model of drug involvement. Addict Behav. 1997 Mar-Apr; 22(2):257-61. View in: PubMed

  217. Hedeker D, Mermelstein RJ. Application of random-effects regression models in relapse research. Addiction. 1996 Dec; 91 Suppl:S211-29. View in: PubMed

  218. Levy PS, Hedeker D. Statistical and epidemiological treatment of the SEER incidence data. J Neuropathol Exp Neurol. 1996 Dec; 55(12):1280. View in: PubMed

  219. Hedeker D, Flay BR, Petraitis J. Estimating individual influences of behavioral intentions: an application of random-effects modeling to the theory of reasoned action. J Consult Clin Psychol. 1996 Feb; 64(1):109-20. View in: PubMed

  220. Clarke AS, Hedeker DR, Ebert MH, Schmidt DE, McKinney WT, Kraemer GW. Rearing experience and biogenic amine activity in infant rhesus monkeys. Biol Psychiatry. 1996 Sep 01; 40(5):338-52. View in: PubMed

  221. Hedeker D, Gibbons RD. MIXREG: a computer program for mixed-effects regression analysis with autocorrelated errors. Comput Methods Programs Biomed. 1996 May; 49(3):229-52. View in: PubMed

  222. Hu FB, Hedeker D, Flay BR, Sussman S, Day LE, Siddiqui O. The patterns and predictors of smokeless tobacco onset among urban public school teenagers. Am J Prev Med. 1996 Jan-Feb; 12(1):22-8. View in: PubMed

  223. Hedeker D, Gibbons RD. MIXOR: a computer program for mixed-effects ordinal regression analysis. Comput Methods Programs Biomed. 1996 Mar; 49(2):157-76. View in: PubMed

  224. Siddiqui O, Hedeker D, Flay BR, Hu FB. Intraclass correlation estimates in a school-based smoking prevention study. Outcome and mediating variables, by sex and ethnicity. Am J Epidemiol. 1996 Aug 15; 144(4):425-33. View in: PubMed

  225. Goldman MB, Robertson GL, Hedeker D. Oropharyngeal regulation of water balance in polydipsic schizophrenics. Clin Endocrinol (Oxf). 1996 Jan; 44(1):31-7. View in: PubMed

  226. Goldman MB, Robertson GL, Luchins DJ, Hedeker D. The influence of polydipsia on water excretion in hyponatremic, polydipsic, schizophrenic patients. J Clin Endocrinol Metab. 1996 Apr; 81(4):1465-70. View in: PubMed

  227. Conrad KJ, Budiman-Mak E, Roach KE, Hedeker D, Caraballada R, Burks D, Moore H. Impacts of foot orthoses on pain and disability in rheumatoid arthritics. J Clin Epidemiol. 1996 Jan; 49(1):1-7. View in: PubMed

  228. Goldman MB, Blake L, Marks RC, Hedeker D, Luchins DJ. Association of nonsuppression of cortisol on the DST with primary polydipsia in chronic schizophrenia. Am J Psychiatry. 1993 Apr; 150(4):653-5. View in: PubMed

  229. Gruder CL, Mermelstein RJ, Kirkendol S, Hedeker D, Wong SC, Schreckengost J, Warnecke RB, Burzette R, Miller TQ. Effects of social support and relapse prevention training as adjuncts to a televised smoking-cessation intervention. J Consult Clin Psychol. 1993 Feb; 61(1):113-20. View in: PubMed

  230. Appleby L, Desai PN, Luchins DJ, Gibbons RD, Hedeker DR. Length of stay and recidivism in schizophrenia: a study of public psychiatric hospital patients. Am J Psychiatry. 1993 Jan; 150(1):72-6. View in: PubMed

  231. Gibbons RD, Hedeker D, Elkin I, Waternaux C, Kraemer HC, Greenhouse JB, Shea MT, Imber SD, Sotsky SM, Watkins JT. Some conceptual and statistical issues in analysis of longitudinal psychiatric data. Application to the NIMH treatment of Depression Collaborative Research Program dataset. Arch Gen Psychiatry. 1993 Sep; 50(9):739-50. View in: PubMed

  232. Nader MA, Hedeker D, Woolverton WL. Behavioral economics and drug choice: effects of unit price on cocaine self-administration by monkeys. Drug Alcohol Depend. 1993 Sep; 33(2):193-9. View in: PubMed

  233. Gibbons RD, Hedeker D. Application of random-effects probit regression models. J Consult Clin Psychol. 1994 Apr; 62(2):285-96. View in: PubMed

  234. Flay BR, Hu FB, Siddiqui O, Day LE, Hedeker D, Petraitis J, Richardson J, Sussman S. Differential influence of parental smoking and friends' smoking on adolescent initiation and escalation of smoking. J Health Soc Behav. 1994 Sep; 35(3):248-65. View in: PubMed

  235. Salina D, Jason LA, Hedeker D, Kaufman J, Lesondak L, McMahon SD, Taylor S, Kimball P. A follow-up of a media-based, worksite smoking cessation program. Am J Community Psychol. 1994 Apr; 22(2):257-71. View in: PubMed

  236. Hedeker D, Gibbons RD, Flay BR. Random-effects regression models for clustered data with an example from smoking prevention research. J Consult Clin Psychol. 1994 Aug; 62(4):757-65. View in: PubMed

  237. Altman EG, Hedeker DR, Janicak PG, Peterson JL, Davis JM. The Clinician-Administered Rating Scale for Mania (CARS-M): development, reliability, and validity. Biol Psychiatry. 1994 Jul 15; 36(2):124-34. View in: PubMed

  238. Hedeker D, Gibbons RD. A random-effects ordinal regression model for multilevel analysis. Biometrics. 1994 Dec; 50(4):933-44. View in: PubMed

  239. Hedeker D, McMahon SD, Jason LA, Salina D. Analysis of clustered data in community psychology: with an example from a worksite smoking cessation project. Am J Community Psychol. 1994 Oct; 22(5):595-615. View in: PubMed

  240. Flay BR, Miller TQ, Hedeker D, Siddiqui O, Britton CF, Brannon BR, Johnson CA, Hansen WB, Sussman S, Dent C. The television, school, and family smoking prevention and cessation project. VIII. Student outcomes and mediating variables. Prev Med. 1995 Jan; 24(1):29-40. View in: PubMed

  241. Levy SR, Weeks K, Handler A, Perhats C, Franck JA, Hedeker D, Zhu C, Flay BR. A longitudinal comparison of the AIDS-related attitudes and knowledge of parents and their children. Fam Plann Perspect. 1995 Jan-Feb; 27(1):4-10, 17. View in: PubMed

  242. Levy PS, Hedeker D, Sanders PG. Aspartame and headache. Neurology. 1995 Aug; 45(8):1631-2; author reply 1632-3. View in: PubMed

  243. Elkin I, Gibbons RD, Shea MT, Sotsky SM, Watkins JT, Pilkonis PA, Hedeker D. Initial severity and differential treatment outcome in the National Institute of Mental Health Treatment of Depression Collaborative Research Program. J Consult Clin Psychol. 1995 Oct; 63(5):841-7. View in: PubMed

  244. Frisch PR, Charles SC, Gibbons RD, Hedeker D. Role of previous claims and specialty on the effectiveness of risk-management education for office-based physicians. West J Med. 1995 Oct; 163(4):346-50. View in: PubMed

  245. Fawcett J, Clark DC, Scheftner WA, Hedeker D. Differences between anhedonic and normally hedonic depressive states. Am J Psychiatry. 1983 Aug; 140(8):1027-30. View in: PubMed

  246. Fawcett J, Scheftner W, Clark D, Hedeker D, Gibbons R, Coryell W. Clinical predictors of suicide in patients with major affective disorders: a controlled prospective study. Am J Psychiatry. 1987 Jan; 144(1):35-40. View in: PubMed

  247. Janicak PG, Davis JM, Chan C, Altman E, Hedeker D. Failure of urinary MHPG levels to predict treatment response in patients with unipolar depression. Am J Psychiatry. 1986 Nov; 143(11):1398-402. View in: PubMed

  248. de Wit H, Uhlenhuth EH, Hedeker D, McCracken SG, Johanson CE. Lack of preference for diazepam in anxious volunteers. Arch Gen Psychiatry. 1986 Jun; 43(6):533-41. View in: PubMed

  249. Gibbons RD, Hedeker D, Davis JM. Regression toward the mean: more on the price of beer and the salaries of priests. Psychoneuroendocrinology. 1987; 12(3):185-92. View in: PubMed

  250. Chan CH, Janicak PG, Davis JM, Altman E, Andriukaitis S, Hedeker D. Response of psychotic and nonpsychotic depressed patients to tricyclic antidepressants. J Clin Psychiatry. 1987 May; 48(5):197-200. View in: PubMed

  251. Clark DC, Daugherty SR, Zeldow PB, Gotterer GS, Hedeker D. The relationship between academic performance and severity of depressed mood during medical school. Compr Psychiatry. 1988 Jul-Aug; 29(4):409-20. View in: PubMed

  252. Gibbons RD, Hedeker D, Waternaux C, Davis JM. Random regression models: a comprehensive approach to the analysis of longitudinal psychiatric data. Psychopharmacol Bull. 1988; 24(3):438-43. View in: PubMed

  253. Hedeker D, Gibbons RD, Waternaux C, Davis JM. Investigating drug plasma levels and clinical response using random regression models. Psychopharmacol Bull. 1989; 25(2):227-31. View in: PubMed

  254. Clark DC, Sommerfeldt L, Schwarz M, Hedeker D, Watel L. Physical recklessness in adolescence. Trait or byproduct of depressive/suicidal states? J Nerv Ment Dis. 1990 Jul; 178(7):423-33. View in: PubMed

  255. Fawcett J, Scheftner WA, Fogg L, Clark DC, Young MA, Hedeker D, Gibbons R. Time-related predictors of suicide in major affective disorder. Am J Psychiatry. 1990 Sep; 147(9):1189-94. View in: PubMed

  256. Javaid JI, Janicak PG, Hedeker D, Sharma RP, Davis JM. Steady-state plasma level prediction for haloperidol from a single test dose. Psychopharmacol Bull. 1991; 27(1):83-8. View in: PubMed

  257. Hedeker D, Gibbons RD, Davis JM. Random regression models for multicenter clinical trials data. Psychopharmacol Bull. 1991; 27(1):73-7. View in: PubMed

  258. Gibbons RD, Davis JM, Hedeker DR. A comment on the selection of 'healthy controls' for psychiatric experiments. Arch Gen Psychiatry. 1990 Aug; 47(8):785-6. View in: PubMed

  259. Sharma R, Hedeker D, Pandey G, Janicak P, Davis J. A longitudinal study of plasma cortisol and depressive symptomatology by random regression analysis. Biol Psychiatry. 1992 Feb 01; 31(3):304-14. View in: PubMed

  260. Clark DC, Daugherty SR, Baldwin DC, Hughes PH, Storr CL, Hedeker D. Assessment of drug involvement: applications to a sample of physicians in training. Br J Addict. 1992 Dec; 87(12):1649-62. View in: PubMed

  261. Charles SC, Gibbons RD, Frisch PR, Pyskoty CE, Hedeker D, Singha NK. Predicting risk for medical malpractice claims using quality-of-care characteristics. West J Med. 1992 Oct; 157(4):433-9. View in: PubMed

  262. Casper RC, Hedeker D, McClough JF. Personality dimensions in eating disorders and their relevance for subtyping. J Am Acad Child Adolesc Psychiatry. 1992 Sep; 31(5):830-40. View in: PubMed

  263. Goldman MB, Marks RC, Blake L, Petkovic M, Hedeker D, Luchins DJ. Estimating daily urine volume in psychiatric patients: empiric confirmation. Biol Psychiatry. 1992 Jun 15; 31(12):1228-31. View in: PubMed