The generalized 3+3 (G3) design for Phase I trials: A design for clinicians.
The generalized 3+3 (G3) design for Phase I trials: A design for clinicians. Contemp Clin Trials. 2025 Nov; 158:108077.
PMID: 40947049
Circulating molecules reflect imaging biomarkers of hemorrhage in cerebral cavernous malformations.
Circulating molecules reflect imaging biomarkers of hemorrhage in cerebral cavernous malformations. J Cereb Blood Flow Metab. 2025 Jun; 45(6):1153-1165.
PMID: 39829356
Prediction of chronic kidney disease progression using recurrent neural network and electronic health records.
Prediction of chronic kidney disease progression using recurrent neural network and electronic health records. Sci Rep. 2023 12 13; 13(1):22091.
PMID: 38086905
A Multi-Arm Two-Stage (MATS) design for proof-of-concept and dose optimization in early-phase oncology trials.
A Multi-Arm Two-Stage (MATS) design for proof-of-concept and dose optimization in early-phase oncology trials. Contemp Clin Trials. 2023 09; 132:107278.
PMID: 37419308
Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma.
Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma. Commun Med (Lond). 2023 Mar 03; 3(1):35.
PMID: 36869161
Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease.
Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease. Transl Stroke Res. 2023 08; 14(4):513-529.
PMID: 35715588
Practical Impact of Modern Dose-Finding Designs When Compared With the 3 + 3 Design: An Editorial.
Practical Impact of Modern Dose-Finding Designs When Compared With the 3 + 3 Design: An Editorial. JCO Precis Oncol. 2021 11; 5:1584-1587.
PMID: 34994645
RoBoT: a robust Bayesian hypothesis testing method for basket trials.
RoBoT: a robust Bayesian hypothesis testing method for basket trials. Biostatistics. 2021 10 13; 22(4):897-912.
PMID: 32061093
Perfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage.
Perfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage. J Cereb Blood Flow Metab. 2021 11; 41(11):2944-2956.
PMID: 34039038
Hi3 + 3: A model-assisted dose-finding design borrowing historical data.
Hi3 + 3: A model-assisted dose-finding design borrowing historical data. Contemp Clin Trials. 2021 10; 109:106437.
PMID: 34020007
Elected Fellow
The American Statistical Association
2020
Mitchell Prize
ISBA
2015